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how to build muscle: 6 tactics, from your rep range to your last meal

October 31, 202616 min read
“The programming is idiotproof. The work is hard though.”
Dr. Andy Galpin, Huberman Lab

the short version

short on time to listen?

paste any long episode into Podex and get the tactics, each with one concrete step, in a few minutes. that is how this list was built.

the six tactics

01

any rep range from 5 to 30, close to failure: Dr. Andy Galpin on Huberman Lab

24 tactics in ~206 minutes (12347s). 10.4M views on YouTube, per the Podex page. Galpin, a professor of kinesiology, walks Huberman through strength, size and endurance. this play is tactic 05, Hypertrophy Lives In The Five-To-Thirty Rep Range.

the fight about the perfect rep range is mostly noise. on the transcript, Galpin's answer for size is "anywhere between five to 30 reps per set. That's going to show across the literature pretty much equal hypertrophy gains." heavy sets of 5, light sets of 30, it all works.

the tactic: pick any range, then finish the set honestly. there is one condition. "The only caveat for hypertrophy is you have to take it to muscular failure." he softens that right away: "You want to train to failure, but you don't need to go to extreme failure." you just have to get close. since the range is so wide, he says you can use it for variety: "Mondays are my sets of 10 days, Wednesdays are my set of 20 days, and Fridays are my set of 30 days." one warning from him: sets of 30 burn, and your mind will want to quit around rep 20.

try this week: for every exercise, pick one rep target between 8 and 30. choose a weight that makes the last two reps a real fight. write down the weight and reps of every working set.

Tactic 01

Dr. Andy Galpin, Huberman Lab

Match Your Variables To The Adaptation You Want

The play

Name your adaptation target first, then set your training variables to match it before choosing any exercise.

Dr. Andy Galpin says

I tell people the exercise you pick does not decide the adaptation you get. What actually determines the outcome is the sets, reps, and rest ranges you apply to that exercise. If you want to get stronger but use the wrong set and rep range, you'll end up with muscular endurance instead of strength.

Try this

Set your sets, reps, and rest ranges to match your target adaptation, not just the exercise.

From Dr. Andy Galpin: How to Build Strength, Muscle Size & Endurance →
02

count your weekly sets, 10 is the floor: Dr. Andy Galpin on Huberman Lab

8 tactics in ~38 minutes (2286s). 256K views on YouTube, per the Podex page. the Essentials cut of Galpin's second guest series episode. this play is tactic 02, Hit 10 To 20 Sets Per Muscle Per Week, Stop Two Reps Short.

if Galpin had to pick one number for growth, it is hard sets per muscle per week. on the transcript of the full episode this Essentials cut comes from: "the kind of minimum number we're going to look for here is 10 working sets." per week, per muscle. in his longer episode he adds: "10 is kind of the minimum. You probably want to look for more like 15 to 20". and he does not want you to obsess over it: "If you're anywhere between 10 to 25 working sets, you know you're fine."

the tactic: count hard sets, stop about two reps short. a working set only counts if it ends close to failure. his number: "A good number to think about is minus two, which is what we call reps in reserve". so stop when you could do about two more good reps. Huberman's solo episode sets the bottom line: "about five sets per week is what's required just to maintain your muscle."

try this week: list the muscles you care about. next to each one, tally the hard sets you did this week. move any muscle under 10 up by two or three sets next week.

03

cap it at 5 to 8 sets per muscle per session: Dr Mike Israetel on Modern Wisdom

7 tactics in ~120 minutes (7179s). 3.3M views on YouTube, per the Podex page. Israetel, an exercise scientist, gives Chris Williamson a crash course in training for size. this play is tactic 03, Stop Junk Volume At Five To Eight Sets Per Muscle Per Session.

more weekly sets help, but not all in one day. on the transcript, Israetel says "The total amount of working sets is by far the biggest determinant of how much muscle you're going to grow per session." up to a point. past it you hit what he calls junk volume: your nervous system is so tired that fewer muscle fibers do the work, and you go through the motions.

the tactic: spread the sets across the week. citing a review of the research, he puts the best average at "something like five to eight working sets per muscle per session." 15 sets for biceps in one go is mostly wasted: "It's like frying an egg after it's already fried." so if you need 15 sets a week, do them in two or three sessions. and keep most sets a little shy of failure: "You can recover from more if you stay a little shy of failure." Huberman's solo episode adds a time limit: workouts work best between 45 and 60 minutes.

try this week: find your biggest single-session set count for any muscle. if it is above 8, cut it to 6 and move the extra sets to a second day that week.

04

check that the target muscle did the work: Dr. Andy Galpin and Andrew Huberman

two episodes. Galpin's long one (entry 1), tactic 06, Use The Three-Indicator Check To Confirm A Muscle Is Actually Working. and Huberman's solo episode: 6 tactics in ~118 minutes (7101s), 6.7M views, tactic 02, The Mind-Muscle Contraction Test.

you can do all the sets and still train the wrong muscle. Galpin's check (he credits Israetel for it) asks three questions about the target muscle. during the set: "are you feeling the glute contract?" after: "Did you feel a big pump afterwards?" the next day: "Did you feel a little bit of soreness there at all?" three no's: "Don't expect much growth." he scores each from 1 to 10: "If you can get three, three and three, you're probably in a pretty good spot."

the tactic: test the connection before you add load. Huberman's version, on the transcript: "march across your body mentally and see whether or not you can independently contract any or all of your muscles." muscles you can squeeze hard on command tend to grow with fewer sets. for muscles you struggle to feel, "it's going to take more sets in order to stimulate the desired effect in those muscles, not fewer."

try this week: after each session, rate the target muscle 1 to 10 for contraction, pump and next-day soreness. any muscle stuck under 3 on all three gets two extra sets next week.

Tactic 01

Andrew Huberman, Huberman Lab

The Burn Is A Beacon, Not A Warning

The play

When you feel the burn, breathe deeply through your nose instead of stopping or holding your breath.

Andrew Huberman says

The burning sensation during exercise is acidity, and lactate shows up to buffer that acidity and act as fuel, not to cause the burn. Engaging this burn for about 10 percent of a workout or activity allows lactate to travel to the heart, liver and brain and enhance their function in positive ways. When you feel the burn, take deep inhales to bring more oxygen into your system rather than holding your breath. The burn is not necessarily a signal to stop, it is a signal that lactate should come in and allow you to continue, unless you are doing something unsafe.

Try this

During about 10 percent of your workout, push into the burning sensation and focus on deep nasal inhales instead of holding your breath.

From Science of Muscle Growth, Increasing Strength & Muscular Recovery →
05

same lifts for six weeks, a bit more each week: Galpin and Israetel

back to Galpin's Essentials episode (entry 2), tactic 04, Standardize Your Exercises For Six To Twelve Weeks, and tactic 06, Cycle Progression Blocks Then Deload. Israetel (entry 3) adds tactic 05, Progress Linearly Until You Can't.

the program-hopper's problem: you never do the same lift long enough to beat it. on the full episode transcript, Galpin: "a major mistake folks do make is they change their exercises entirely way too often." his rule if he had to pick: "don't change anything on your exercises for six weeks." he says 10 to 12 weeks is realistic too.

the tactic: same lifts, small jumps, planned rest. Israetel's version: start a few reps away from failure, then "next week add a little bit of load, add a rep or two, and go up, up, up." that cannot go on forever. if you train hard four to six times a week, "Most people can't last longer than about four to eight weeks." when your joints ache, sleep slips and you do not want to train, he takes "a week of half of everything". that is a deload. then start the climb again.

try this week: write down your exercises and freeze them for six weeks. each week, add one rep or the smallest weight jump to every lift. put a lighter week in your calendar for week six.

Tactic 01

Dr. Andy Galpin, Huberman Lab

Run The Three To Five Method

The play

Run three to five exercises for three to five sets of three to five reps, resting three to five minutes, three to five days a week, adding 3 to 5% load weekly for about five weeks before a deload.

Dr. Andy Galpin says

I structure strength and power training around a three to five framework, covering days, exercises, reps, sets, and rest. The structure only works if every rep is executed at high intent. I progress the load by about 3 to 5% per week within that structure.

Try this

Build your week around three to five exercises, sets, reps, and rest minutes, then add load weekly at high intent.

From Essentials: Optimal Protocols to Build Strength & Grow Muscles | Dr. Andy Galpin →
06

1.6 g of protein per kilo, no ice bath after lifting: Norton and Huberman

Norton on Huberman Lab: 6 tactics in ~226 minutes (13543s), 8.8M views per the Podex page, tactic 02, Target 1.6 Grams Of Protein Per Kilogram Of Body Weight Daily. Huberman's solo episode (entry 4) covers tactic 05, What Kills Your Gains After The Session Ends.

training is the signal. food and recovery turn it into muscle. Norton, a nutrition scientist and powerlifter, on the transcript: "Of the macronutrients, protein is definitely the biggest lever that you can pull". his number: "I would shoot for 1.6 grams per kilogram. If you can do more, great." that is about 0.7 g per pound, so roughly 128 g a day if you weigh 80 kg. Huberman adds that "you need to have a caloric surplus of about 10 to 15%" to gain muscle, and that most people do fine eating two to four times a day.

the tactic: do not cancel the session afterwards. Huberman: "cold after resistance training seems to short-circuit some of the benefits of that resistance training." athletes who need fast recovery or mostly train endurance may still choose cold, he says. if size is the goal, keep the ice bath off lifting days.

try this week: multiply your body weight in kg by 1.6. that is your daily protein target. hit it on five days this week. on lifting days, skip cold showers and ice baths after training.

a one-week plan to build muscle

pick by problem

Huberman LabFREE

you keep switching programs and rep schemes: Dr. Andy Galpin.

the play: pick any rep range from 5 to 30 and take each set close to failure. [open on Podex](https://www.getpodex.com/episodes/andy-galpin-build-strength-muscle-size-endurance)

Huberman LabFREE

you train hard but have no idea if it is enough: Dr. Andy Galpin.

the play: count hard sets per muscle per week. 10 is the floor, 15 to 20 is the target. [open on Podex](https://www.getpodex.com/episodes/essentials-optimal-protocols-to-build-strength-grow-muscles-dr-andy-galpin)

Modern WisdomFREE

your sessions last two hours and you leave wrecked: Dr Mike Israetel.

the play: cap each muscle at 5 to 8 hard sets per session and spread the rest across the week. [open on Podex](https://www.getpodex.com/episodes/mw-israetel-stimulus-to-fatigue)

Huberman LabFREE

you never feel the muscle you are training: Andrew Huberman.

the play: run the mind-muscle test, then add sets for the muscles you struggle to feel. [open on Podex](https://www.getpodex.com/episodes/science-of-muscle-growth-increasing-strength-muscular-recovery)

Huberman LabFREE

your lifts have been stuck for months: Dr. Andy Galpin.

the play: same exercises for six weeks, small jumps every week, then a lighter week. [open on Podex](https://www.getpodex.com/episodes/essentials-optimal-protocols-to-build-strength-grow-muscles-dr-andy-galpin)

Huberman LabFREE

you train well but eat like you do not: Dr. Layne Norton.

the play: about 1.6 g of protein per kg of body weight every day. [open on Podex](https://www.getpodex.com/episodes/the-science-of-eating-for-health-fat-loss-lean-muscle-dr-layne-norton)

what this is not

want the locked tactics too?

every page above has more plays behind the free one: Galpin's 360-degree core tension and hydration equation, Israetel's four-factor rest model, Huberman's CO2 recovery test. tactics, not takeaways.

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FAQ

How do you build muscle?

Lift with enough hard sets: Dr. Andy Galpin puts the floor at about 10 working sets per muscle per week, with 15 to 20 as a better target. Any rep range from 5 to 30 works if you finish each set close to failure. Keep your exercises the same for at least six weeks, add a rep or a little weight each week, and eat enough protein.

How many sets per week do you need to build muscle?

Dr. Andy Galpin says about 10 working sets per muscle per week is the minimum, and 15 to 20 is more realistic for most people who have trained a while. Andrew Huberman says about five sets per week is roughly what it takes just to maintain a muscle. Dr Mike Israetel suggests spreading the sets so each session has about 5 to 8 per muscle.

How many reps should I do to build muscle?

Dr. Andy Galpin says anywhere from 5 to 30 reps per set gives about equal muscle growth in the research, as long as you take the set close to failure. He suggests mixing ranges for variety, for example sets of 10 one day, 20 another and 30 another.

Do you have to train to failure to build muscle?

Close to it, but not all the way. Galpin suggests stopping about two reps short, which is called two reps in reserve. Dr Mike Israetel says going to failure every set gives slightly more growth per set but much more fatigue, so you can recover from more total work if you stay a little shy of failure.

How much protein do I need to build muscle?

Dr. Layne Norton says the muscle building benefits of protein start to level off around 1.6 grams per kilogram of body weight per day, about 0.7 grams per pound, and that more is fine. Andrew Huberman says eating two to four times a day works for most people.

Are ice baths bad for muscle growth?

Andrew Huberman says cold exposure right after resistance training seems to short-circuit some of the benefits of that training. If building muscle is your goal, keep cold showers and ice baths away from your lifting sessions. Athletes who need fast recovery or who mostly train endurance may still choose cold.

What is the Andy Galpin 3 to 5 method?

It is Galpin's template for strength and power: three to five exercises, three to five sets of three to five reps, three to five minutes of rest, three to five days a week. For size, he uses higher weekly volume instead, at least 10 hard sets per muscle per week.

What are the best podcast episodes about building muscle?

Dr. Andy Galpin on Huberman Lab (How to Build Strength, Muscle Size & Endurance, plus the Essentials episode on Optimal Protocols to Build Strength & Grow Muscles), Andrew Huberman's solo episode on the Science of Muscle Growth, Dr Mike Israetel on Modern Wisdom, and Dr. Layne Norton on Huberman Lab for nutrition.