Build an Edge So Deep No One Can See It From the Outside
Shkreli spent years becoming one of the most knowledgeable people in the world on pharmaceutical clinical trials — not just the results, but the design, the statistical methodology, the failure modes, the FDA approval probability math. When he looked at a biotech stock, he wasn't guessing. He was calculating. His edge wasn't access or speed — it was depth. He knew things about specific drug pipelines that most investors, including professionals, simply didn't have the background to know. 'An edge based on information processing depth is sustainable. An edge based on access or tips disappears.'
The play
Pick one specific domain — one industry, one asset class, one niche — and go 10x deeper than any generalist would. Read everything. Talk to practitioners. Build the framework that lets you see what others miss.